Supporting Research

1. Calcium sulfate antibiotic-impregnated bead implantation for deep surgical site infection associated with orthopedic surgery in small animals

Peterson L, Kim S, Lewis D, Johnson M, Ferrigno C. Calcium sulfate antibiotic-impregnated bead implantation for deep surgical site infection associated with orthopedic surgery in small animals. Vet Surg. 2021 Jan 25

2. The efficacy of antibiotic-impregnated calcium sulfate (AICS) in the treatment of infected non-union and fracture-related infection: a systematic review

Jacob CC, Daw JH, Santiago-Torres J. The efficacy of antibiotic-impregnated calcium sulfate (AICS) in the treatment of infected non-union and fracture-related infection: a systematic review. J Bone Jt Infect. 2023 Mar 22;8(2):91-97. doi: 10.5194/jbji-8-91-2023. PMID: 37123503; PMCID: PMC10134749

3. Pancarpal Arthrodesis Using Antibiotic–Impregnated Calcium Sulfate Beads in a Dog with Septic Arthritis and Osteomyelitis

Davenport, Amy & Bird, Frances & Vallefuoco, Rosario. (2024). Pancarpal Arthrodesis Using Antibiotic–Impregnated Calcium Sulfate Beads in a Dog with Septic Arthritis and Osteomyelitis. VCOT Open. 07. e40-e45. 10.1055/s-0044-1785214.

4. Single-Stage Revision of an Infected Total Hip Replacement Using Antibiotic-Impregnated Bioabsorbable Beads in a Canine Patient

Guthrie J, Fitzpatrick N. Single-Stage Revision of an Infected Total Hip Replacement Using Antibiotic-Impregnated Bioabsorbable Beads in a Canine Patient. VCOT Open 2019 02(01):e5-e12

5. Use of antimicrobial impregnated calcium sulphate beads in the surgical management of mandibular osteomyelitis in an 8-year-old huacaya alpaca

Po E, Allen MJ, Whitelock RG, Elsayed SH. Use of antimicrobial impregnated calcium sulphate beads in the surgical management of mandibular osteomyelitis in an 8-year-old huacaya alpaca. Vet Rec Case Rep. 2022;e301.

6. Clinical application of tobramycin-impregnated calcium sulfate beads in six dogs (2002-2004)

Ham K, Griffon D, Seddighi M, Johnson AL. Clinical application of tobramycin-impregnated calcium sulfate beads in six dogs (2002-2004).  J Am Anim Hosp Assoc. 2008 Nov-Dec;44(6):320-6.

7. Single-stage treatment of chronic localized tibial osteomyelitis with local debridement and antibiotic-loaded calcium sulfate implantation: a retrospective study of 42 patients

Zhou CH, Ren Y, Ali A, Meng XQ, Zhang HA, Fang J, Qin CH. Single-stage treatment of chronic localized tibial osteomyelitis with local debridement and antibiotic-loaded calcium sulfate implantation: a retrospective study of 42 patients. J Orthop Surg Res. 2020 Jun 1

8. Use of Antibiotic-Impregnated Absorbable Beads and Tissue Coverage of Complex Wounds

White TL, Culliford AT, Zomaya M, Freed G, Demas CP. Use of Antibiotic-Impregnated Absorbable Beads and Tissue Coverage of Complex Wounds. Am Surg. 2016 Nov 1

9. Managing lower-extremity osteomyelitis locally with surgical debridement and synthetic calcium sulfate antibiotic tablets

Gauland C. Managing lower-extremity osteomyelitis locally with surgical debridement and synthetic calcium sulfate antibiotic tablets. Adv Skin Wound Care. 2011 Nov;24(11):515-23.

10. Complete Killing of Agar Lawn Biofilms by Systematic Spacing of Antibiotic-Loaded Calcium Sulfate Beads

Dusane D, Brooks J, Sindeldecker D, Peters C, Li A, Farrar N, Diamond S, Knecht C, Plaut R, Delury C, Aiken S, Laycock P, Sullivan A, Granger J, Stoodley P. Complete Killing of Agar Lawn Biofilms by Systematic Spacing of Antibiotic-Loaded Calcium Sulfate Beads. Materials (Basel). 2019 Dec; 12(24): 4052

11. Decrease in acute periprosthetic joint infections incidence with vancomycin loaded calcium sulfate beads in patients with non-modifiable risk factors. A randomized clinical trial

de Lachica JCV, Reyes SSS, Ureña JAP, Fragoso MAR. Decrease in acute periprosthetic joint infections incidence with vancomycin-loaded calcium sulfate beads in patients with non-modifiable risk factors. A randomized clinical trial. J ISAKOS. 2022 Dec;7

12. Surgical intervention for vertebral osteomyelitis in a calf

Shivapour SK, et al. Surgical intervention for vertebral osteomyelitis in a calf. Vet Surg. 2019 Aug;48

13. Assessing the Bioactive Profile of Antifungal-Loaded Calcium Sulfate against Fungal Biofilms

Butcher M, Brown J, Hansom D, Wilson-van Os R, Delury C, Laycock P, Ramage G. Assessing the Bioactive Profile of Antifungal-Loaded Calcium Sulfate against Fungal Biofilms. Antimicrobial Chemotherapy. 18 May 2021

14. Reduction in Pseudomonas aeruginosa and Staphylococcus aureus biofilms from implant materials in a diffusion dominated environment

Moley JP, McGrath MS, Granger JF, Stoodley P, Dusane DH. Reduction in Pseudomonas aeruginosa and Staphylococcus aureus biofilms from implant materials in a diffusion dominated environment. J Orthop Res. 2018 Nov;36 (11)

15. Use of Vancomycin-Impregnated Calcium Sulfate in the Treatment of Osteomyelitis of the Jaw

Sun HJ, Xue L, Wu CB, Zhou Q. Use of Vancomycin-Impregnated Calcium Sulfate in the Treatment of Osteomyelitis of the Jaw. J Oral Maxillofac Surg. 2017 Jan;75(1):119-128.

16. Bio-absorbable antibiotic impregnated beads for the treatment of prosthetic vascular graft infections

Genovese EA, Avgerinos ED, Baril DT, Makaroun MS, Chaer RA. Bio-absorbable antibiotic impregnated beads for the treatment of prosthetic vascular graft infections. Vascular. 2016 Dec;24(6):590-597.

17. Antibiotic-loaded calcium sulfate in clinical treatment of chronic osteomyelitis: a systematic review and meta-analysis

Shi X, Wu Y, Ni H, Li M, Zhang C, Qi B, Wei M, Wang T, Xu Y. Antibiotic-loaded calcium sulfate in clinical treatment of chronic osteomyelitis: a systematic review and meta-analysis. J Orthop Surg Res. 2022 Feb 19

1. Plasma and interstitial fluid antibiotic levels of subcutaneously implanted compounded florfenicol calcium sulfate beads in New Zealand White rabbits (Oryctolagus cuniculus)

Partyka M, Divers S, Cruz-Espindola C, Weyna AAW, Gottdenker NL, Burns L, Trumpp K, Boothe DM. Plasma and interstitial fluid antibiotic levels of subcutaneously implanted compounded florfenicol calcium sulfate beads in New Zealand White rabbits (Oryctolagus cuniculus). Am J Vet Res. 2024 May 18:1-10. doi: 10.2460/ajvr.24.02.0044. Epub ahead of print. PMID: 38744313.

2. Local and Systemic Levels of Tobramycin Delivered from Calcium Sulfate Bone Graft Substitute Pellets

Turner TM, Urban RM, Hall DJ, Chye PC, Segreti J, Gitelis S. Local and systemic levels of tobramycin delivered from calcium sulfate bone graft substitute pellets. Clin Orthop Relat Res. 2005 Aug;(437):97-104.

3. Evaluation of comparative soft tissue response to bone void fillers with antibiotics in a rabbit intramuscular model

Oliver R, Lovric V, Christou C, Walsh W. Evaluation of comparative soft tissue response to bone void fillers with antibiotics in a rabbit intramuscular model. J Biomater Appl. 2019 Jul; 34(1): 117–129.

4. The levels of vancomycin in the blood and the wound after the local treatment of bone and soft-tissue infection with antibiotic-loaded calcium sulphate as carrier material

Wahl P, et al. The levels of vancomycin in the blood and the wound after the local treatment of bone and soft-tissue infection with antibiotic-loaded calcium sulphate as carrier material. Bone Joint J. 2017 Nov;99-B(11):1537-1544. doi: 10.1302/0301-620X.99B11.BJJ-2016-0298.R3.

5. Development of a Novel Model for the Assessment of Dead-Space Management in Soft Tissue

Oliver RA, Lovric V, Yu Y, Christou C, Aiken SS, Cooper JJ, Walsh WR. Development of a Novel Model for the Assessment of Dead-Space Management in Soft Tissue. PLoS One. 2015 Aug 25;10(8):e0136514.

6. Careful interpretation of the wound status is needed with use of antibiotic impregnated biodegradable synthetic pure calcium sulfate beads: Series of 39 cases

Menon A,Soman R, Rodrigues C, Phadke S, Agashe VM. Careful interpretation of the wound status is needed with use of antibiotic impregnated biodegradable synthetic pure calcium sulfate beads: Series of 39 cases. J Bone Jt Infect. 2018 May 15;3(2):87-93

7. Simulated large joint fluid model for evaluating intra-articular antibiotic delivery systems: initial evaluation using antibiotic-loaded calcium sulfate beads

McPherson EJ, Jennings JA, Yunis O, Harris MA, Dipane MV, Curtin NL, Chowdhry M, Wassef AJ, Bumgardner JD, Noel SP. Simulated large joint fluid model for evaluating intra-articular antibiotic delivery systems: initial evaluation using antibiotic-loaded calcium sulfate beads. J Bone Jt Infect. 2022 May 17

8. The treatment of experimental osteomyelitis by surgical debridement and the implantation of calcium sulfate tobramycin pellets

Nelson CL, McLaren SG, Skinner RA, Smeltzer MS, Thomas JR, Olsen KM. The treatment of experimental osteomyelitis by surgical debridement and the implantation of calcium sulfate tobramycin pellets. J Orthop Res. 2002 Jul;20(4):643-7.

9. Low in vitro third-body wear on total hip prostheses induced by calcium sulphate used for local antibiotic therapy

Heuberger R, Wahl P, Krieg J, Gautier E. Low in vitro third-body wear on total hip prostheses induced by calcium sulphate used for local antibiotic therapy. Eur Cell Mater. 2014 Oct 23;28:246-57.

1. Bead size has a greater effect on in vitro elution from antimicrobial-impregnated calcium sulfate beads than drug concentration

Olsen RS, Sawyere DM, Davis JL, Lanz OI, Werre SR. Bead size has a greater effect on in vitro elution from antimicrobial-impregnated calcium sulfate beads than drug concentration. Am J Vet Res. 2023 Mar 11

2. Effects of storage up to 1 year on the in vitro antimicrobial activity of preformulated antibiotic-impregnated calcium sulfate beads

Hartman EA, Pena Hernandez D, Hendrix GK, Risselada M, Weng HY, Papich MG, Kim SY. Effects of storage up to 1 year on the in vitro antimicrobial activity of preformulated antibiotic-impregnated calcium sulfate beads. Vet Surg. 2023 Aug 13. doi: 10.1111/vsu.14014. Epub ahead of print. PMID: 37574868.

3. In vitro Elution of Gentamicin From Plaster of Paris Beads

Santschi EM, McGarvey L. In vitro elution of gentamicin from Plaster of Paris beads. Vet Surg. 2003 Mar-Apr;32(2):128-33.

4. In vitro elution characteristics of antibiotic-loaded polymethylmethacrylate cement and a calcium sulfate bone substitute using staphylococci isolated from orthopedic implant-associated infections

Batista Campos L, Kurihara MNL, Santos INM, Dos Reis FB, Salles MJ. In vitro elution characteristics of antibiotic-loaded polymethylmethacrylate cement and a calcium sulfate bone substitute using staphylococci isolated from orthopedic implant-associated infections. J Biomed Mater Res B Appl Biomater. 2023 Jun

5. In Vitro Efficacy of Antibiotics Released from Calcium Sulfate Bone Void Filler Beads

Laycock PA, Cooper JJ, Howlin RP, Delury C, Aiken S, Stoodley P. In Vitro Efficacy of Antibiotics Released from Calcium Sulfate Bone Void Filler Beads. Materials (Basel). 2018 Nov 13;11(11).

6. Identifying alternative antibiotics that elute from calcium sulfate beads for treatment of orthopedic infections

Levack A, Turajane K, Driscoll D, Yang X, Miller A, Bostrom M, Wellman D, Carli A. Identifying alternative antibiotics that elute from calcium sulfate beads for treatment of orthopedic infections. J Orthop Res. 2021 Jun 30]

7. Elution profiles of cefazolin from PMMA and calcium sulfate beads prepared from commercial cefazolin formulations

Udomkusonsri P1, Kaewmokul S, Arthitvong S, Phaochoosak N. Elution profiles of cefazolin from PMMA and calcium sulfate beads prepared from commercial cefazolin formulations. J Vet Med Sci. 2012 Mar;74(3):301-5.

8. Local release of antibiotics for surgical site infection management using high-purity calcium sulfate: an in vitro elution study

Aiken SS, Cooper JJ, Florance H, Robinson MT, Michell S. Local release of antibiotics for surgical site infection management using high-purity calcium sulfate: an in vitro elution study. Surg Infect (Larchmt). 2015 Feb;16(1):54-61.

9. Elution Profiles of Synthetic CaSO4 Hemihydrate Beads Loaded with Vancomycin and Tobramycin

Maale G, Eager J, Mohammadi D, Calderon F. Elution Profiles of Synthetic CaSO 4 Hemihydrate Beads Loaded with Vancomycin and Tobramycin. Eur J Drug Metab Pharmacokinet. 2020; 45(4): 547–555

10. Antimicrobial Formulations of Absorbable Bone Substitute Materials as Drug Carriers Based on Calcium Sulfate

Pförringer D, Obermeier A, Kiokekli M, Büchner H, Vogt S, Stemberger A, Burgkart R, Lucke M. Antimicrobial Formulations of Absorbable Bone Substitute Materials as Drug Carriers Based on Calcium Sulfate. Antimicrob Agents Chemother. 2016 Jun 20;60(7):3897-905.

11. Elution of Clindamycin and Enrofloxacin From Calcium Sulfate Hemihydrate Beads In Vitro

Phillips H, Boothe D, Bennett R. Avery. Elution of Clindamycin and Enrofloxacin From Calcium Sulfate Hemihydrate Beads In Vitro. Vet Surg. 2015 Nov;44(8):1003-11

12. The in vitro elution characteristics of antifungal-loaded PMMA bone cement and calcium sulfate bone substitute

Grimsrud, C., Raven, R., Fothergill, A. W., & Kim, H. T. The in vitro elution characteristics of antifungal-loaded PMMA bone cement and calcium sulfate bone substitute. Orthopedics. 2011 34(8).

13. Evaluation of bioabsorbable calcium sulfate hemihydrate beads for local delivery of carboplatin

Traverson M, Stewart C, Papich M. Evaluation of bioabsorbable calcium sulfate hemihydrate beads for local delivery of carboplatin. PLoS One. 2020; 15(11): e0241718.