1. Calcium sulfate antibiotic-impregnated bead implantation for deep surgical site infection associated with orthopedic surgery in small animals
Peterson L, Kim S, Lewis D, Johnson M, Ferrigno C. Calcium sulfate antibiotic-impregnated bead implantation for deep surgical site infection associated with orthopedic surgery in small animals. Vet Surg. 2021 Jan 25
2. Antibiotic-loaded calcium sulfate in clinical treatment of chronic osteomyelitis: a systematic review and meta-analysis
Shi X, Wu Y, Ni H, Li M, Zhang C, Qi B, Wei M, Wang T, Xu Y. Antibiotic-loaded calcium sulfate in clinical treatment of chronic osteomyelitis: a systematic review and meta-analysis. J Orthop Surg Res. 2022 Feb 19
3. Decrease in acute periprosthetic joint infections incidence with vancomycin loaded calcium sulfate beads in patients with non-modifiable risk factors. A randomized clinical trial
de Lachica JCV, Reyes SSS, Ureña JAP, Fragoso MAR. Decrease in acute periprosthetic joint infections incidence with vancomycin-loaded calcium sulfate beads in patients with non-modifiable risk factors. A randomized clinical trial. J ISAKOS. 2022 Dec;7
4. Efficacy of Topical Vancomycin- and Gentamicin-Loaded Calcium Sulfate Beads or Systemic Antibiotics in Eradicating Polymicrobial Biofilms Isolated from Diabetic Foot Infections within an In Vitro Wound Model
Crowther GS, Callaghan N, Bayliss M, Noel A, Morley R, Price B. Efficacy of Topical Vancomycin- and Gentamicin-Loaded Calcium Sulfate Beads or Systemic Antibiotics in Eradicating Polymicrobial Biofilms Isolated from Diabetic Foot Infections within an In Vitro Wound Model. Antimicrob Agents Chemother. 2021 May 18
5. Clinical application of tobramycin-impregnated calcium sulfate beads in six dogs (2002-2004)
Ham K, Griffon D, Seddighi M, Johnson AL. Clinical application of tobramycin-impregnated calcium sulfate beads in six dogs (2002-2004). J Am Anim Hosp Assoc. 2008 Nov-Dec;44(6):320-6.
6. Managing lower-extremity osteomyelitis locally with surgical debridement and synthetic calcium sulfate antibiotic tablets
Gauland C. Managing lower-extremity osteomyelitis locally with surgical debridement and synthetic calcium sulfate antibiotic tablets. Adv Skin Wound Care. 2011 Nov;24(11):515-23.
7. Antibiotic-loaded synthetic calcium sulfate beads for prevention of bacterial colonization and biofilm formation in periprosthetic infections
Howlin RP, Brayford MJ, Webb JS, Cooper JJ, Aiken SS, Stoodley P. Antibiotic-loaded synthetic calcium sulfate beads for prevention of bacterial colonization and biofilm formation in periprosthetic infections. Antimicrob Agents Chemother. 2015 Jan;59(1):111-20
8. Reduction in Pseudomonas aeruginosa and Staphylococcus aureus biofilms from implant materials in a diffusion dominated environment
Moley JP, McGrath MS, Granger JF, Stoodley P, Dusane DH. Reduction in Pseudomonas aeruginosa and Staphylococcus aureus biofilms from implant materials in a diffusion dominated environment. J Orthop Res. 2018 Nov;36 (11)
9. Complete Killing of Agar Lawn Biofilms by Systematic Spacing of Antibiotic-Loaded Calcium Sulfate Beads
Dusane D, Brooks J, Sindeldecker D, Peters C, Li A, Farrar N, Diamond S, Knecht C, Plaut R, Delury C, Aiken S, Laycock P, Sullivan A, Granger J, Stoodley P. Complete Killing of Agar Lawn Biofilms by Systematic Spacing of Antibiotic-Loaded Calcium Sulfate Beads. Materials (Basel). 2019 Dec; 12(24): 4052
10. A Single Center Retrospective Evaluation of a Surgical Strategy to Combat Persistent Soft Tissue Wounds Utilizing Absorbable Antibiotic Beads
Gorvetzian J, Kunkel R, Demas C. A Single Center Retrospective Evaluation of a Surgical Strategy to Combat Persistent Soft Tissue Wounds Utilizing Absorbable Antibiotic Beads. Adv Wound Care (New Rochelle). 2019 Feb 1; 8(2): 49–57.
11. Tobramycin-impregnated calcium sulfate prevents infection in contaminated wounds
Thomas DB, Brooks DE, Bice TG, DeJong ES, Lonergan KT, Wenke JC. Tobramycin-impregnated calcium sulfate prevents infection in contaminated wounds. Clinical Orthopaedics & Related Research. 2005; 441:366-271
12. A prospective, randomized clinical trial comparing an antibiotic-impregnated bioabsorbable bone substitute with standard antibiotic-impregnated cement beads in the treatment of chronic osteomyelitis and infected nonunion
McKee MD, Li-Bland EA, Wild LM, Schemitsch EH. A prospective, randomized clinical trial comparing an antibiotic-impregnated bioabsorbable bone substitute with standard antibiotic-impregnated cement beads in the treatment of chronic osteomyelitis and infected nonunion. J Orthop Trauma. 2010 Aug;24(8):483-90.
13. Effectiveness of commercially-available antibiotic-impregnated implants
Wenke JC, Owens BD, Svoboda SJ, Brooks DE. Effectiveness of commercially-available antibiotic-impregnated implants. J Bone Joint Surg Br. 2006 Aug;88(8):1102-4.
14. In Vitro Activity of Gentamicin-Loaded Bioabsorbable Beads against Different Microorganisms
Thein E, Tafin UF, Betrisey B, Trampuz A, Borens O. In Vitro Activity of Gentamicin-Loaded Bioabsorbable Beads against Different Microorganisms. Materials (Basel). 2013 Aug 5;6(8):3284-3293.
1. Local and Systemic Levels of Tobramycin Delivered from Calcium Sulfate Bone Graft Substitute Pellets
Turner TM, Urban RM, Hall DJ, Chye PC, Segreti J, Gitelis S. Local and systemic levels of tobramycin delivered from calcium sulfate bone graft substitute pellets. Clin Orthop Relat Res. 2005 Aug;(437):97-104.
2. Evaluation of comparative soft tissue response to bone void fillers with antibiotics in a rabbit intramuscular model
Oliver R, Lovric V, Christou C, Walsh W. Evaluation of comparative soft tissue response to bone void fillers with antibiotics in a rabbit intramuscular model. J Biomater Appl. 2019 Jul; 34(1): 117–129.
3. The levels of vancomycin in the blood and the wound after the local treatment of bone and soft-tissue infection with antibiotic-loaded calcium sulphate as carrier material
Wahl P, et al. The levels of vancomycin in the blood and the wound after the local treatment of bone and soft-tissue infection with antibiotic-loaded calcium sulphate as carrier material. Bone Joint J. 2017 Nov;99-B(11):1537-1544. doi: 10.1302/0301-620X.99B11.BJJ-2016-0298.R3.
4. Development of a Novel Model for the Assessment of Dead-Space Management in Soft Tissue
Oliver RA, Lovric V, Yu Y, Christou C, Aiken SS, Cooper JJ, Walsh WR. Development of a Novel Model for the Assessment of Dead-Space Management in Soft Tissue. PLoS One. 2015 Aug 25;10(8):e0136514.
5. Careful interpretation of the wound status is needed with use of antibiotic impregnated biodegradable synthetic pure calcium sulfate beads: Series of 39 cases
Menon A,Soman R, Rodrigues C, Phadke S, Agashe VM. Careful interpretation of the wound status is needed with use of antibiotic impregnated biodegradable synthetic pure calcium sulfate beads: Series of 39 cases. J Bone Jt Infect. 2018 May 15;3(2):87-93
6. Simulated large joint fluid model for evaluating intra-articular antibiotic delivery systems: initial evaluation using antibiotic-loaded calcium sulfate beads
McPherson EJ, Jennings JA, Yunis O, Harris MA, Dipane MV, Curtin NL, Chowdhry M, Wassef AJ, Bumgardner JD, Noel SP. Simulated large joint fluid model for evaluating intra-articular antibiotic delivery systems: initial evaluation using antibiotic-loaded calcium sulfate beads. J Bone Jt Infect. 2022 May 17
7. The treatment of experimental osteomyelitis by surgical debridement and the implantation of calcium sulfate tobramycin pellets
Nelson CL, McLaren SG, Skinner RA, Smeltzer MS, Thomas JR, Olsen KM. The treatment of experimental osteomyelitis by surgical debridement and the implantation of calcium sulfate tobramycin pellets. J Orthop Res. 2002 Jul;20(4):643-7.
8. Low in vitro third-body wear on total hip prostheses induced by calcium sulphate used for local antibiotic therapy
Heuberger R, Wahl P, Krieg J, Gautier E. Low in vitro third-body wear on total hip prostheses induced by calcium sulphate used for local antibiotic therapy. Eur Cell Mater. 2014 Oct 23;28:246-57.
1. Bead size has a greater effect on in vitro elution from antimicrobial-impregnated calcium sulfate beads than drug concentration
Olsen RS, Sawyere DM, Davis JL, Lanz OI, Werre SR. Bead size has a greater effect on in vitro elution from antimicrobial-impregnated calcium sulfate beads than drug concentration. Am J Vet Res. 2023 Mar 11
2. In vitro Elution of Gentamicin From Plaster of Paris Beads
Santschi EM, McGarvey L. In vitro elution of gentamicin from Plaster of Paris beads. Vet Surg. 2003 Mar-Apr;32(2):128-33.
3. In vitro elution characteristics of antibiotic-loaded polymethylmethacrylate cement and a calcium sulfate bone substitute using staphylococci isolated from orthopedic implant-associated infections
Batista Campos L, Kurihara MNL, Santos INM, Dos Reis FB, Salles MJ. In vitro elution characteristics of antibiotic-loaded polymethylmethacrylate cement and a calcium sulfate bone substitute using staphylococci isolated from orthopedic implant-associated infections. J Biomed Mater Res B Appl Biomater. 2023 Jun
4. In Vitro Efficacy of Antibiotics Released from Calcium Sulfate Bone Void Filler Beads
Laycock PA, Cooper JJ, Howlin RP, Delury C, Aiken S, Stoodley P. In Vitro Efficacy of Antibiotics Released from Calcium Sulfate Bone Void Filler Beads. Materials (Basel). 2018 Nov 13;11(11).
5. Identifying alternative antibiotics that elute from calcium sulfate beads for treatment of orthopedic infections
Levack A, Turajane K, Driscoll D, Yang X, Miller A, Bostrom M, Wellman D, Carli A. Identifying alternative antibiotics that elute from calcium sulfate beads for treatment of orthopedic infections. J Orthop Res. 2021 Jun 30]
6. Elution profiles of cefazolin from PMMA and calcium sulfate beads prepared from commercial cefazolin formulations
Udomkusonsri P1, Kaewmokul S, Arthitvong S, Phaochoosak N. Elution profiles of cefazolin from PMMA and calcium sulfate beads prepared from commercial cefazolin formulations. J Vet Med Sci. 2012 Mar;74(3):301-5.
7. Local release of antibiotics for surgical site infection management using high-purity calcium sulfate: an in vitro elution study
Aiken SS, Cooper JJ, Florance H, Robinson MT, Michell S. Local release of antibiotics for surgical site infection management using high-purity calcium sulfate: an in vitro elution study. Surg Infect (Larchmt). 2015 Feb;16(1):54-61.
8. Elution Profiles of Synthetic CaSO4 Hemihydrate Beads Loaded with Vancomycin and Tobramycin
Maale G, Eager J, Mohammadi D, Calderon F. Elution Profiles of Synthetic CaSO 4 Hemihydrate Beads Loaded with Vancomycin and Tobramycin. Eur J Drug Metab Pharmacokinet. 2020; 45(4): 547–555
9. Antimicrobial Formulations of Absorbable Bone Substitute Materials as Drug Carriers Based on Calcium Sulfate
Pförringer D, Obermeier A, Kiokekli M, Büchner H, Vogt S, Stemberger A, Burgkart R, Lucke M. Antimicrobial Formulations of Absorbable Bone Substitute Materials as Drug Carriers Based on Calcium Sulfate. Antimicrob Agents Chemother. 2016 Jun 20;60(7):3897-905.
10. Elution of Clindamycin and Enrofloxacin From Calcium Sulfate Hemihydrate Beads In Vitro
Phillips H, Boothe D, Bennett R. Avery. Elution of Clindamycin and Enrofloxacin From Calcium Sulfate Hemihydrate Beads In Vitro. Vet Surg. 2015 Nov;44(8):1003-11
11. The in vitro elution characteristics of antifungal-loaded PMMA bone cement and calcium sulfate bone substitute
Grimsrud, C., Raven, R., Fothergill, A. W., & Kim, H. T. The in vitro elution characteristics of antifungal-loaded PMMA bone cement and calcium sulfate bone substitute. Orthopedics. 2011 34(8).
12. Evaluation of bioabsorbable calcium sulfate hemihydrate beads for local delivery of carboplatin
Traverson M, Stewart C, Papich M. Evaluation of bioabsorbable calcium sulfate hemihydrate beads for local delivery of carboplatin. PLoS One. 2020; 15(11): e0241718.
1. Use of antimicrobial impregnated calcium sulphate beads in the surgical management of mandibular osteomyelitis in an 8-year-old huacaya alpaca
Po E, Allen MJ, Whitelock RG, Elsayed SH. Use of antimicrobial impregnated calcium sulphate beads in the surgical management of mandibular osteomyelitis in an 8-year-old huacaya alpaca. Vet Rec Case Rep. 2022;e301.
2. Single-Stage Revision of an Infected Total Hip Replacement Using Antibiotic-Impregnated Bioabsorbable Beads in a Canine Patient
Guthrie J, Fitzpatrick N. Single-Stage Revision of an Infected Total Hip Replacement Using Antibiotic-Impregnated Bioabsorbable Beads in a Canine Patient. VCOT Open 2019 02(01):e5-e12
3. Use of Antibiotic-Impregnated Absorbable Beads and Tissue Coverage of Complex Wounds
White TL, Culliford AT, Zomaya M, Freed G, Demas CP. Use of Antibiotic-Impregnated Absorbable Beads and Tissue Coverage of Complex Wounds. Am Surg. 2016 Nov 1
4. Treatment of chronic long-bone infections by dissolvable antibiotic beads (pure synthetic calcium sulfate impregnated with vancomycin and gentamicin)
Henawy, Ayman T.. Treatment of chronic long-bone infections by dissolvable antibiotic beads (pure synthetic calcium sulfate impregnated with vancomycin and gentamicin). The Egyptian Orthopaedic Journal 54(3):p 193-198, Jul–Sep 2019
5. Antibiotic-impregnated calcium sulfate use in combat-related open fractures
Helgeson MD, Potter BK, Tucker CJ, Frisch HM, Shawen SB. Antibiotic-impregnated calcium sulfate use in combat-related open fractures. Orthopedics. 2009 May;32(5):323.
6. Dissolvable Antibiotic Beads in Treatment of Periprosthetic Joint Infection and Revision Arthroplasty - The Use of Synthetic Pure Calcium Sulfate Impregnated with Vancomycin & Tobramycin
Edward McPherson, MD FACS, Matthew Dipane, BA, Sherif Sherif, MD Dissolvable Antibiotic Beads in Treatment of Periprosthetic Joint Infection and Revision Arthroplasty – The Use of Synthetic Pure Calcium Sulfate Impregnated with Vancomycin & Tobramycin. Reconstructive Review. 2013; 3:1.
7. Assessing the Bioactive Profile of Antifungal-Loaded Calcium Sulfate against Fungal Biofilms
Butcher M, Brown J, Hansom D, Wilson-van Os R, Delury C, Laycock P, Ramage G. Assessing the Bioactive Profile of Antifungal-Loaded Calcium Sulfate against Fungal Biofilms. Antimicrobial Chemotherapy. 18 May 2021
8. Gastrocnemius muscle flap with vancomycin/gentamicin-calcium sulfate and autogenous iliac bone graft for the phase I treatment of localized osteomyelitis after tibial plateau fracture surgery
Ruan W, Li M, Guo Q, Lin B. Gastrocnemius muscle flap with vancomycin/gentamicin-calcium sulfate and autogenous iliac bone graft for the phase I treatment of localized osteomyelitis after tibial plateau fracture surgery. J Orthop Surg Res. 2021 May 27
9. Single-stage treatment of chronic localized tibial osteomyelitis with local debridement and antibiotic-loaded calcium sulfate implantation: a retrospective study of 42 patients
Zhou CH, Ren Y, Ali A, Meng XQ, Zhang HA, Fang J, Qin CH. Single-stage treatment of chronic localized tibial osteomyelitis with local debridement and antibiotic-loaded calcium sulfate implantation: a retrospective study of 42 patients. J Orthop Surg Res. 2020 Jun 1
10. Implant retention with serial debridement and use of antibiotic-loaded calcium sulfate beads in acute fracture-related infection (FRI) after pelvic ring or acetabular fractures: A retrospective case series of 7 cases
Casiraghi A, Galante C, Rohayem M, Vittone G, Domenicucci M, Cattaneo S, Paderno M, Grava G, Van Hauwermeiren E, Milano G. Implant retention with serial debridement and use of antibiotic-loaded calcium sulfate beads in acute fracture-related infection (FRI) after pelvic ring or acetabular fractures: A retrospective case series of 7 cases. Injury. 2023 Apr
11. Development of a Novel Collagen Wound Model To Simulate the Activity and Distribution of Antimicrobials in Soft Tissue during Diabetic Foot Infection
Price BL, Lovering AM, Bowling FL, Dobson CB. Development of a Novel Collagen Wound Model To Simulate the Activity and Distribution of Antimicrobials in Soft Tissue during Diabetic Foot Infection. Antimicrob Agents Chemother. 2016 Oct 21;60(11):6880-6889.
12. Surgical intervention for vertebral osteomyelitis in a calf
Shivapour SK, et al. Surgical intervention for vertebral osteomyelitis in a calf. Vet Surg. 2019 Aug;48
13. How to Use Antibiotic Impregnated Plaster of Paris for Alveolar Packing after Tooth Removal
Trostle S, Juzwiak J, Santschi, E. How to Use Antibiotic Impregnated Plaster of Paris for Alveolar Packing after Tooth Removal. AAEP Proceedings. 2000 Vol. 46
14. Use of Vancomycin-Impregnated Calcium Sulfate in the Treatment of Osteomyelitis of the Jaw
Sun HJ, Xue L, Wu CB, Zhou Q. Use of Vancomycin-Impregnated Calcium Sulfate in the Treatment of Osteomyelitis of the Jaw. J Oral Maxillofac Surg. 2017 Jan;75(1):119-128.
15. Simplified Method for Treating Osteomyelitis of the Sternoclavicular Joint
Whitlark JD, Kirollos JA, Jackson SM. Simplified Method for Treating Osteomyelitis of the Sternoclavicular Joint. Ann Thorac Surg. 2016 Mar;101(3):1211-2.
16. Bio-absorbable antibiotic impregnated beads for the treatment of prosthetic vascular graft infections
Genovese EA, Avgerinos ED, Baril DT, Makaroun MS, Chaer RA. Bio-absorbable antibiotic impregnated beads for the treatment of prosthetic vascular graft infections. Vascular. 2016 Dec;24(6):590-597.
17. Absorbable Antibiotic Beads Prophylaxis in Immediate Breast Reconstruction
Kenna DM, Irojah B, Mudge KL, Eveler K. Absorbable Antibiotic Beads Prophylaxis in Immediate Breast Reconstruction. Plast Reconstr Surg. 2017 Dec 13.
